They even had problems with _existing_ fully tested designs where a filler material (presumably some kind of plastic) was produced by a different process and stopped working as it should. (Several million dollars of research later this was discovered to be the lack of a crucial contaminant caused by the process change.) Oops!
Chemical Engineering changes can pose unexpected problems.
Then you have little problems like _this_:
https://landley.net/history/mirror/institutional_memory.html
3:O)>
I have been asked strange questions about old software, including "Do you have any contact details for $Person?" by someone wanting to know about the Y2K fix some 20 years on... (Because they will need to repeat the exercise in 2027 at the latest, but they didn't say that.) I have a broad outline but no specifics, and gave them the LinkedIn profile details - that they had and were not working. Oops!