Good thing that the Reader Q&A on Goodreads answers the very first question I've had about this month's book for the #sffbookclub: Yes, it sounds like this can be read without knowing the other entries in the series :D
@zerok They exist in the same universe concept, and can reference each other from time to time, but that's really it.
Le Guin herself says, "The thing is, they aren't a cycle or a saga. They do not form a coherent history. There are some clear connections among them, yes, but also some extremely murky ones."